Specific Profiles and Amplification of Resistance to Anti-tuberculosis Drugs in Tuberculosis Patients in the Republic of Karelia

The objective: to determine the frequency of resistance Mycobacterium tuberculosis (MTB) most effective anti-tuberculosis drugs in patients Republic Karelia, characterize cases amplification MTB drug during chemotherapy (CT). Subjects and Methods. cultures 1,137 were studied, received from 2016 2021, among them 634 (55.8%) had multiple (MDR). Among MBT with MDR, there was a high extensive (XDR) – 42.3% (268/634) including new cases. It provided negative impact on efficacy. Most often, observed treated as per regimen IV 37/49 (75.5%) amplified more often who already resistant 3 drugs, 31/49 (63.3%). noted aminoglycosides (Km, Am) glycopeptide (Cm), (71.6% cases). MDR up XDR due lack rapid molecular genetic methods test susceptibility fluoroquinolones aminoglycosides.